Let’s say it plainly.
A blood test measures the delivery route.
A urine test measures trash removal.
Neither tells you what’s stored, active, and signaling inside your tissues.
And that’s the blind spot.
Endocrinology textbooks are clear on this:
a hormone molecule isn’t “one and done.”
It can stay in tissue —
knocking on that cell’s door again and again,
long after it’s vanished from your blood.
This is why labs can look perfect
while symptoms keep getting louder.
And if you’re on hormone therapy, this matters — a lot.
Because if hormones accumulate in tissue,
that daily dose might not be replacing anything.
You may be stacking it.
Day after day.
Creating tissue overload —
even while bloodwork stays “normal.”
This isn’t about scaring anyone off treatment.
It’s about understanding how hormones actually behave.
Because biology doesn’t lie —
but incomplete testing often does.
