Hormones are built from cholesterol → fat-soluble → they don’t mix with blood like oil and water.
That’s why your body calls in SHBG (Sex Hormone Binding Globulin) — think of it as the Uber for your hormones.
It picks them up, drives them through the bloodstream, and drops them off at tissues where the real work happens.
But here’s what actually matters (and what most labs miss):
🚗 It’s not how many Ubers are on the road (total hormones).
🚗 It’s how many actually get dropped off and work inside the tissues (bioavailable/free hormones).
Symptoms? They show up when the balance is off: too much binding → not enough action at the tissue level → energy dips, mood shifts, weight resistance, even with “normal” blood results.
Blood measures delivery.
Tissues measure function.
Understanding SHBG + bioavailable hormones is key to real midlife clarity—no guessing, just physiology.
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